(2) Generally located at branch points, the sub-clones that appear to have good fitness, or are selected for at later tumour TPs, contained CLL drivers (ITPKB, NFKBIE, SF3B1, TP53 and ZMYM3) or genes mutated in other haematoloical malignancies (ITGA6 andLTF) supporting the role of genes in the latter two categories as candidate drivers of progression in those patients. The gene discussed is NFKBIE; the disease is B-cell chronic lymphocytic leukemia.