However, WES did identify 10 mutated genes from which two candidates emerged, namely missense mutations in ZBTB7C a kidney cancer-related gene that interacts with p53 (ref. 29 and S1PR4 a receptor expressed in hematopoietic cells that interacts with MAPK3 (ERK1), placing it in the B-cell receptor pathway.30 The gene discussed is S1PR4; the disease is kidney cancer.