Although, GLI group of transcription factors are the major modulators of HH-GLI pathway, it is also known to be activated non-canonically by other signaling molecules e.g. RAS, RAF, MEK, ERK, etc. Synthetic agents (e.g. GDC-0449, IPI-926, GANT61) and siRNA based GLI knockdown leads to tumor disappearance, inhibition of tumor recurrence both in vitro and in vivo29. This evidence concerns the gene MAP2K7 and neoplasm.