Although we did not find a significant correlation between the expression of HIF-1α and HIF-2α with gender, age, calcification, or Hashimoto’s disease in the present study (P > 0.05), both of their expressions were correlated to lymph node metastasis (P < 0.05), capsular invasion (P < 0.05), and TNM stage (P < 0.05). This evidence concerns the gene EPAS1 and metastatic malignant neoplasm in the lymph nodes.