Additionally, chi-square test showed a significant association between the presence of lymph node metastasis with HIF-1α (P = 0.006) and HIF-2α expression (P = 0.037).There was also a statistical significance between capsular invasion with the expression of HIF-1α (P = 0.012) and HIF-2α (P = 0.004). This evidence concerns the gene HIF1A and metastatic malignant neoplasm in the lymph nodes.