Finally, the regression model confirmed that MetS diagnosis and wHGPIN are predictive variables for subsequent PCa diagnosis (respectively OR 2.79, 95 % IC 1.49–5.22, p = 0.01 and OR 2.4, 95 % IC 1.01–5.71, p = 0.04) while PSA, PSA free, DRE findings, fasting glucose, blood hypertension status, BMI, plasma triglycerides are not able for that purpose (Table 4). Here, KLK3 is linked to Hypertension.