TNF and preterm premature rupture of the membranes: When we compared controls with PPROM, the alleles TLR2A (rs4696480) (p = 0.007) and TNFA-238G (p = 0.009) (Table 5) as well as the genotypes TLR2 AA (p = 0.004) and TNFA-238 GG (p = 0.012) (data not shown) were associated with this complication .