The aim of this study was to evaluate the contribution of maternal and fetal SNPs in the IL1B, IL6, IL6R, TNFA, TNFR, IL10, TLR2, TLR4, MMP9, TIMP1 and TIMP2 genes and the influence of the ancestry background in the susceptibility to PTL or PPROM in Brazilian women. Here, IL6 is linked to preterm premature rupture of the membranes.