Data showed that DLC-1 mRNA expression was lost in 95 % of patient with NSCLC tumors tissues and 58 % of NSCLC cell lines, due at least in part through its function as a RhoGAP and thus negatively regulating the expression of RhoA and related RhoB, RhoC [8]. This evidence concerns the gene DLC1 and non-small cell lung carcinoma.