As indicated in the RNA-seq data analysis (Figs 1 and 2), any correlation between SOX2 and CDKN1B in the various lung SCC cell lines was not observed at the protein level (Fig. 3A,C), which suggests that SOX2 regulates CDKN1B in a cell-type specific fashion (pancreatic cancer vs. lung SCC). The gene discussed is SOX2; the disease is familial pancreatic carcinoma.