Among the genes whose expression that we identified as positively correlated with SOX2 (BMP7, CHAC1, DHX9, GPX2, MARK1, MSH6, PRKX, RMND5A, SIAH2, TMPRSS4 and USP39) in our bioinformatical analysis using both the 178 lung SCC specimens and 105 NSCLC cell lines, all of them were originally reported as top 50 genes that are positively correlated with SOX2 in stage I/II lung SCC11, indicating that our approach is valid and useful to identify gene correlation and potential downstream targets in lung SCC cells. The gene discussed is TMPRSS4; the disease is non-small cell lung carcinoma.