By demonstrating the direct inhibitory effect of nor-NOHA on oleic acid-induced triglyceride synthesis with concurrent increase in NO production and AMPK signaling in HepG2 hepatocytes in vitro, they conclude that arginase inhibition reduces obesity-induced hepatic lipid abnormality most likely attributable to the inhibition of Arg-I. Here, LNCARGI is linked to obesity due to melanocortin 4 receptor deficiency.