AIF1 and congenital hydrocephalus: Intraperitoneal administration of minocycline to H-Tx rats with congenital hydrocephalus from postnatal day 15 to day 21 was associated with increased cortical thickness (ventricle size was not measured) and reduced cerebral immunolabeling for Iba-1 (a microglial marker) and GFAP (an astrocyte marker) [239].