TGFB1 and Hydrocephalus: Intracerebroventricular infusion of recombinant human hepatocyte growth factor, which antagonizes the fibrosis-inducing effect of TGF-β1, for 7 or 14 days, improved the memory, ventricle size, CSF flow, and meningeal fibrosis in mice with TGF-β1 injection-induced hydrocephalus [168].