PLAU and focal segmental glomerulosclerosis: The ratio of IgG1/IgG2a + IgG3 was significantly increased in the WT group from W1, but there was no change in the uPA−/− group (Fig. 4), suggesting that uPA−/− mice fail to generate a type 2 immune response which may contribute to acceleration of Adriamycin-induced FSGS.