The de novo expression of integrin αvβ6 has been shown to modulate several behaviors of colon carcinoma cells, including cell adhesion and spreading on fibronectin, proliferation in collagen gels, tumor growth, cell invasion and metastasis, and cell apoptosis, which we demonstrated throughout our 20-year investigation of integrin αvβ623, 24, 25, 26. This evidence concerns the gene FN1 and colon carcinoma.