Genetic analysis of BBS patients have identified nineteen disease responsible genes (BBS1-19), most of which encode BBSome protein (BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9/PTHB1, BBS17/LZTFL1 and BBS18/BBIP1) while some produce basal body interacting protein (BSS13/MKS1, BBS14/EP290/NPHP6, BBS15/WDPCP and BBS16/SDCCAG8), chaperonin complex protein (MKKS, BBS10 and BBS12), E3 ubiquitin ligase (BBS11/TRIM32), and a GTPase protein complex (BBS3/ARL6 and BBS19/IFT27) [10, 11]. This evidence concerns the gene TTC8 and Bardet-Biedl syndrome.