CASP3 and lung cancer: However, genotoxic CT may activate both caspase-dependent and -independent cell-death pathways.34 Tumour growth in a lung cancer xenograft was significantly delayed by Caspase-3 inhibition, and tumours also displayed reduced vascularisation, highlighting the role of Caspase-3 in tumour growth and progression.29 Nevertheless, antagonising the repopulation pathway downstream of Caspase-3 may offer a more attractive alternative, allowing for cell-death induction but preventing proliferation signatures from being activated.