Using this model, we treated 19 fresh colon tumours taken at surgery with 5FU-based CT (30 μg 5FU/10 μg Oxaliplatin) alone and in combination with a specific Caspase-3 inhibitor, Ac-DLND-CHO19 (30 μg 5FU/10 μg Oxali+200 nM Ac-DNLD-CHO; hereafter DLND) and COX-2 inhibitors Aspirin and Celecoxib (30 μg 5FU/10 μg Oxali+2.5 mM Aspirin and 30 μg 5FU/10 μg Oxali+50 μM Celecoxib). The gene discussed is CASP3; the disease is colonic neoplasm.