CASP3 and neoplasm: Consequently, tumours with high EMT often have a poor prognosis.22 The Zinc Finger E-Box Binding Homeobox (ZEB) family of transcription factors is integral to EMT.23 ZEB1 was previously shown to supress E-Cadherin expression via PGE2-mediated signalling.24 Therefore, we investigated whether Caspase-3-driven proliferation might impact EMT (Figure 4e).