PLIN2 and retinal degeneration: The ADRP progression in these animals is characterized by an activated unfolded protein response (UPR) and the mitochondrial dysfunction.1, 2, 3 Recent work conducted with ADRP mice has revealed that the persistently activated UPR could be responsible for promoting retinal degeneration via the activation of an inflammatory response.4 However, in addition to modulated expression of interleukins IL-1b and IL-6, the activated UPR may promote cytotoxicity through Ca2+-depleted ER, thus affecting the function of the mitochondria.5