FGFR1 and neoplasm: Other growth factors (FGF2 and FGF3) and growth factor receptors (FGFR1 and EGFR (epidermal growth factor receptor)) could also mediate their activity by an intracrine/nuclear pathway.5, 6, 33, 34, 35, 36 As most of these nuclear growth factors and/or receptors could exert oncogenic activities, the study of these nuclear pathways could be crucial to identify key regulators involved in tumor progression and/or resistance to radio- and/or chemo-therapy.