This finding is in concordance with previous experiments.3–9 Adiponectin might serve as predictor of NAFLD in obese children.3 Decreased adiponectin levels were the primary hint in the course of NAFLD, even before rise of proinflammatory cytokines.28 Also, adiponectin played an important role in the progression of simple liver steatosis to NASH.29 Low serum adiponectin levels were evident before the development of overt diabetes and obesity.30 Decrease in circulating adiponectin levels was associated with reduced liver insulin sensitivity and increased liver fat content. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.