IL6 and cancer: Cancer-related fatigue has been associated with a number of causative factors, including inflammatory processes, disruption of the hypothalamus-pituitary-adrenal gland axis, as well as metabolic disturbances with decreased ATP production.18 Similar to other flavonols, quercetin is able to decrease TNF-alfa and IL-6 serum levels.19 Preclinical data show that quercetin is able to boost cellular metabolism by increasing the activity of AMPK, a key energy-sensor enzyme that stimulates skeletal muscle fatty acid oxidation and muscle glucose uptake.