First, hyperglycemia may lead to increased superoxide radical formation in vascular endothelial cells and smooth muscle cells by NADPH oxidase through increased formation of mitochondrial reactive oxygen species (ROS) (Paneni et al., 2013) and advanced glycated end products (AGE) (Ago, T, et al., 2011, Goldin, A, et al., 2006). Here, FMO5 is linked to Hyperglycemia.