Indeed, in the mouse, ablation of Bcl9/9l in the intestinal epithelium abrogates the expression of genes related to epithelial–mesenchymal transformation (EMT) and stemness in chemically induced colorectal tumors suggesting that the traits associated with tumor invasion and metastasis via Bcl9/9l appear to be dispensable for normal intestinal epithelial homeostasis (Deka et al. 2010). The gene discussed is BCL9; the disease is colorectal neoplasm.