APC and colorectal carcinoma: They first investigated a second CRC mouse model driven by loss of Apc and oncogenic Kras to complement their initial observations performed on the chemically induced mouse CRC model mentioned above (Deka et al. 2010) confirming that ablation of Bcl9/9l modulates similar alterations of gene expression in both types of tumors with 359 down- and 107 up-regulated common differentially expressed genes.