BCL9 and colorectal carcinoma: In summary, the results by Moor et al. show that inhibiting the BCL9/9L interaction with β-catenin leads to diminished gene expression associated with stemness and EMT traits and promotes differentiation in CRC tumors (in the context as shown previously (Deka et al. 2010) that it remains relatively well tolerated in the normal intestinal epithelium).