IL1B and ischemia: In our research, we compared all the ischemia groups to the sham-operated group and found that ischemia groups have significantly severer neurologic deficits, more TNF-α and IL-1 expression, increased labeling of apoptotic cells, increased CD68 positive staining of brain lesion, and increased volume of infarct and cerebral edema (P < 0.05) in both 24 hours and 7 days after reperfusion.