Eneli et al. (2005) summarize these findings and present five possible (non-exclusive) causal pathways accounting for the role of acetaminophen in asthma exacerbation. An additional immunologic pathway has been hypothesized by Nassini et al. (2010), namely the production of neurogenic airway inflammation caused by the transient receptor potential ankyrin-1 (TRPA1). Farquhar et al. (2010) have proposed another possible acetaminophen–asthma mediating mechanism based on its antipyretic effect. This evidence concerns the gene TRPA1 and asthma.