Most cases of ALS are sporadic with no known genetic linkage, while approximately 10% are associated with familial forms, presenting mutations in over 20 genes encoding for distinct proteins with varied functions, including SOD1, fused in sarcoma (FUS), TDP-43, chromosome 9 open reading frame 72 (C9ORF72), PFN-1, vacuolar protein sorting-associated protein 9- (VPS9-) ankyrin repeat protein (VARP), alsin, ataxin-2, and matrin-3 [194, 218]. This evidence concerns the gene PFN1 and amyotrophic lateral sclerosis.