Furthermore, our initial studies of SH-EP1 epithelioid neuroblastoma cells suggested that manipulating p75NTR expression leads to a coordinate change in CRABP1 expression, and manipulating CRABP1 expression alone (i.e., without manipulation of p75NTR expression) mimics the effects of p75NTR manipulation on fenretinide-induced cell death. This evidence concerns the gene NGFR and neuroblastoma.