Another study by Zia and colleagues showed that the induction of NOX2 could cause OS and worsen brain injury, whereas the inhibition of NOX2 by apocynin suppresses ROS production and confers neuroprotection in rabbit pups with germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) [68]. Here, CYBB is linked to Grade I preterm intraventricular hemorrhage.