An important finding revealed by Trynka et al. [16] is that, on functional annotation of 57 genetic loci associated with celiac disease, only 3 genetic variations, that is, rs1059702 in IRAK1, rs3184504 in SH2B3, and rs3748816 in MMEL1, are found to occur in exonic regions and subsequently affect the amino acid sequences of concerned proteins. The gene discussed is SH2B3; the disease is celiac disease.