Our results indicated that C/EBPA may effectively bind to the rs3733609 T/T loci (Figure 3B), and the region from +86 to +98 was enriched 15.7 fold in the C/EBPA chromatin immunoprecipitates in MPN patients with rs3733609 T/T genotype than those with C/T genotype (P < 0.001, Figure 3C), suggesting that C/EBPA transcript factor mediated the regulation of TET2 gene expression by binding to TET2 exon 9 domain localized at nucleotide +86 to +98 sequences, and the C/T genotype weakened the binding of C/EBPA at this region and down-regulated transcription of the TET2 mRNA. The gene discussed is CEBPA; the disease is myeloproliferative neoplasm.