To further validate that DR5 upregulation underlies TRAIL-induced apoptosis in CABYR-a/b-silenced cells, we treated CABYR-a/b-silenced and control cells with an agonistic DR5 monoclonal antibody, AD5-10, which has been reported to specifically bind to DR5 and induce cancer cell apoptosis [20]. This evidence concerns the gene TNFRSF10B and cancer.