CASP3 and hepatocellular carcinoma: A number of mechanisms may explain the circadian control on HCC, firstly, a down-regulated gene, BMAL2 in HCC may exert the effect of inhibiting the cell proliferation, in turn, overexpression of antisense BMAL2 results in reduced cell cycle time and TNF-α-induced increment of CPP32/caspase-3 activity, and a concomitantly increased G2/S phase transition of cells [144].