Studies reported that miR-490 inhibits bladder cancer proliferation by targeting c-Fos [27], miR-490-3p could directly target nanog in mouse embryonic stem cell [29], and miR-490-3p exert suppressor in growth and metastasis on gastric cancer cells through directly targeting SMARCD1 [24]. The gene discussed is SMARCD1; the disease is urinary bladder cancer.