Moreover, Dapito et al. demonstrated the gut microbiota promote hepatocellular carcinoma (HCC) development in its late stages through the LPS‐Toll‐like receptor 4 (TLR4) pathway 111 but found no evidence that intestinal microbiota and TLR4 have an effect on the initiation of HCC 111. This evidence concerns the gene TLR4 and hepatocellular carcinoma.