Cancer cachexia 801. Systemic inflammation2. Negative energy balance3. Involuntary loss of adipose tissue and skeletal muscleProduction of catabolic mediators such as proinflammatory cytokines (interleukins, interferon‐γ, tumour necrosis factor‐α, NF‐κB) 118, 119Cancer cachexia and Cori cycle 83, 84, 86, 87Increased food intake with body weight loss in mouse tumour model 89Neuroendocrine regulation of appetite in human beings with hepatoblastoma and in neuroblastoma‐transplanted rats 90. This evidence concerns the gene NFKB1 and neoplasm.