In the present study, we found that the post-translational modification site of CAV1 at lysine 176 influenced the formation of CAV1 oligomers and the interaction between CAV1 and P-glycoprotein, which also affected the transport activity of P-glycoprotein in non-small-cell lung cancer cell lines. The gene discussed is ABCB1; the disease is non-small cell lung carcinoma.