PAX5 and large cell carcinoma: The results of chi‐squared test showed that PAX5 methylation was associated with histological type (P = 0.006), among 33 cases of methylation tissues, 18 cases were adenocarcinoma (55%), 10 cases were squamous‐cell carcinoma (30%), 4 cases were lung adenosquamous carcinoma (12%), 1 case was large cell carcinoma (3%).