According to Pawlak et al. [99], MMP-2/TIMP-2 ratio was higher in peritoneal dialysis (CAPD) patients with cardiovascular disease than in patients without CAD and healthy controls, and it was associated with quinolinic acid (QA) levels and increased oxidative status, suggesting the connection between kynurenine (KYN) pathway activation, arterial remodelling and CVD prevalence in uremic patients. The gene discussed is TIMP2; the disease is coronary artery disorder.