In this analysis, the presence of heart failure was associated with the presence of chronic kidney disease, the level of osteopontin, age, MMP-2 and AIP and this relationship was independent of osteocalcin, osteoprotegerin, fetuin, gender, MMP-9, TIMP-1, TIMP-2, MGP, ANGII, ABCA1, ABCG1, non-HDL cholesterol and urea). The gene discussed is SPP1; the disease is heart failure.