TNF and rheumatoid arthritis: On the basis of CDAI remission criteria, despite PD negativity, 2 (13.3 %) of 15 patients with RA experienced disease relapse after tapering TNF blocker treatment and 1 (7.7 %) of 13 patients with RA had disease relapse after biologic discontinuation, compared with 30.9 % and 10.3 % of patients with RA in DAS remission after biologic tapering (p = 0.18) and discontinuation (p = 0.79), respectively.