To conclude, our data confirm that the zebrafish dnm2a knockdown is a valuable model for dynaminopathies and, most importantly, demonstrate that overexpression of human DNM2 mRNAs, containing different disease-related mutations, cause a continuum of pathological features similarly to what observed in human centronuclear myopathies and neuropathies. Here, DNM2 is linked to centronuclear myopathy.