Recurrent chromosomal translocations involving Ig loci and proto-oncogenes such as c-MYC, BCL-2, BCL-6 and FGFR are hallmarks of B-cell malignancies, and are associated with Burkitt's lymphoma, follicular lymphoma, diffuse large cell lymphoma and multiple myeloma, respectively54, 55, 56. The gene discussed is BCL2; the disease is plasma cell myeloma.