CD4+ T cells (CD4+ Tconv), CD8+ T cells and CD4+ CD39+ Treg were isolated from peripheral blood of three normal donors and each isolated subset was individually co-incubated with exosomes isolated from supernatants of cultured tumor cells (TEX) or from supernatants of cultured human dendritic cells (DEX). This evidence concerns the gene ENTPD1 and neoplasm.