Consistent with prior reports [13], we also found that women with preeclampsia in the index pregnancy (n = 10) had markedly higher circulating PTX3 levels, but not CRP levels at all time points in pregnancy; PTX3 (median 25th, 75th); 3.85 (3.49, 6.42) ng/mL at 14–16 weeks, 5.03 (3.71, 6.19) ng/mL at 22–24 weeks, 7.33 (5.45, 10.40) ng/mL at 30–32 weeks, and 11.49 (6.73, 17.71) ng/mL at 36–38 weeks (p < 0.05 compared to non GDM), but not at 5-year follow up [3.53 (2.28, 4.82) ng/mL; p = 0.16]. The gene discussed is CRP; the disease is gestational diabetes.