Support for the role of genetic polymorphism of the FA genes associated with inter-individual susceptibility to lung adenocarcinoma came from the combination of three lines of evidence; Lung adenocarcinomas in both male and female patients were consistently associated with (a) genotypic polymorphisms of FANCC and FANCD1; (b) a combined effect of harboring a higher number of high-risk genotypes and smoking/passive smoking; (c) specific interactions of multiple genes, proteins encoded by which have been known to work jointly within the FA pathway. This evidence concerns the gene FANCA and lung adenocarcinoma.