As noted in Fig. 4, we identified upregulation in the top 10 most significantly dysregulated canonical pathways in EAC with a down regulation of 9 out of 10 pathways in dysplasia (PPARa/RXRa upregulated), down regulation of the top 10 pathways in BE, and down regulation of 9 out of 10 pathways in TANE (upregulation of PPAR). The gene discussed is RXRA; the disease is Barrett esophagus.