Ingenuity Pathway Analysis (IPA) revealed an upregulation of the top 10 most significantly dysregulated canonical pathways in EAC with a down regulation of 9 out of 10 pathways in dysplasia (PPARa/RXRa upregulated), down regulation of the top 10 pathways in BE and down regulation of 9 out of 10 pathways in TANE (upregulation of PPAR) (Additional file 2: Figure S2). Here, RXRA is linked to Barrett esophagus.