TNF and infection: This information would clarify whether DTA has the adverse effects of anti-TNFα blockers and tocilizumab, such as serial infection and tumorigenesis, and clarify the possible mechanism of DTA(A7/sTNFR2), such as translocation of transmembrane TNFα-expressing macrophages to joints with elevated soluble IL-6R or the existence of reverse signaling induced by DTA-bound transmembrane TNFα.