As IL-6 induces the expression of MMP3 and MMP13 in RA-FLS27, we performed realtime RT-PCR to investigate the inhibitory effects of DTA(A7/sTNFR2) on mRNA expression of these genes in RA-FLS incubated with IL-6 and sIL-6R. The gene discussed is MMP3; the disease is rheumatoid arthritis.