As TNFα increased the expression of vascular endothelial growth factor-C (VEGF-C) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in RA-FLS24, 25, 26, we examined the effects of DTA(A7/sTNFR2) on mRNA expression of VEGF-C and GM-CSF using realtime RT-PCR in RA-FLS stimulated with TNFα. This evidence concerns the gene TNF and rheumatoid arthritis.