TNF and arthritic joint disease: Three other bispecific antibodies reduced arthritis in CIA models: Kanakaraj P. et al. described a bispecific antibody that targets TNFα and angiopoetin 121; Qi J. et al. described one against IL-1β and IL-17A21, 22, and Liu M. et al. recently created one that targets TNFα and ED-B fibronectin23.