MAPK14 and squamous cell carcinoma: A different study on Metformin’s effect on human epidermoid carcinoma, shows a similar decrease in the activation of MAPK1433 with a suppressive effect on cancer cell proliferation; another study, shows that Metformin directly decreases the phosphorylation levels of MAPK14 in bovine granulosa cells35, a third study shows that Metformin, used in conjunction with gefitinib, decreased levels of MSH2 protein in human lung squamous cell carcinoma, again, through down regulation of MAPK1434.