Finally, a study on metastatic melanomas shows that activation of MAPK14 by urokinase plasminogen activator receptor (uPAR) clustering on cell surfaces (promoted by d-GM3, a ganglioside) results in the activation of matrix metalloproteinase-2 (MMP-2)36 which contributes to cell migration and metastasis in cancer cells. This evidence concerns the gene MAPK14 and cancer.