Moreover, it has been demonstrated that SNPs rs836478 (C/T) and rs10951982 (G/A) in RAC1 gene were associated with higher level of biomarkers (interleukin 6, metalloproteinase-9, and plasminogen activator inhibitor-1) related to the development and progression of hypertension [27]. This evidence concerns the gene RAC1 and Hypertension.