In our studies we observed no differences in Foxp3/CCR4 mRNA expression in colonic tissue amongst the four groups of mice in an acute colitis model, despite differences in disease by histopathology (Fig 2) and observed no attenuation of protection from DSS-induced acute colitis in CD200tg mice following depletion of CD4+ cells (Fig 3E). Here, CD4 is linked to colitis.