FOXP3 and Chronic colitis: However, in the chronic colitis model, increased expression of both CCR4 and Foxp3 was detected in CD200tg mice (Fig 7A and 7B), with an increased ratio of Foxp3+:CD3+ cells enumerated in the same CD200tg mice both in colonic tissue sections (Fig 5 and Table 2) and by FACS staining of isolated mesenteric lymph node cells (Fig 7C).