Thus, in conditions with increased thrombin or MMP activity, such as obesity-induced AT inflammation [16–18], atherosclerosis [19, 20], rheumatoid arthritis [21], asthma [22, 23], and cancer [24], OPN-neoepitopes with increased adhesive properties are generated. This evidence concerns the gene SPP1 and obesity due to melanocortin 4 receptor deficiency.