DEGs in module up-2, suchas ATP5D, UQCRC2, NDUFA2,NDUFB8, NDUFA7, COX4I1,NDUFA1, NDUFB1, NDUFS7,UQCR11, NDUFV1, NDUFV2, andNDUFS3, were enriched in the pathways of oxidativephosphorylation (P=3.31E-13), Parkinson’s disease (P=3.81E-13), Alzheimer’s disease(P=3.25E-11), and Huntington’s disease (P=7.35E-11; Table 3). The gene discussed is COX4I1; the disease is early-onset autosomal dominant Alzheimer disease.