PRIM1 and lung adenocarcinoma: Lung adenocarcinoma is a form of solid tumor,and its biological behavior including formation, development, and attack is closelyrelated to abnormal cell proliferation, which includes DNA replication.PRIM1 encodes one of the subunits (p49) of the eukaryotic primase,which is a heterodimer consisting of a small and a large subunit that synthesizes RNAprimers for the Okazaki fragments during discontinuous DNA replication (33).