The ability of both CA and FA to prevent HFD-induced hypertriglyceridemia is remarkableand likely to involve i) a direct liver effect to coordinate reduction in theFAS and DGAT-2 expressions during HFD as well as tocoordinate the induction of ATGL and PPARa expressionand/or ii) an indirect effect mediated via prevention of obesity. Here, PNPLA2 is linked to obesity disorder.