APOE and atherosclerosis: Accordingly, the present study was designed to evaluate the selective delivery of 17-βE to aortic atherosclerotic plaque with this CREKA-peptide-modified nanoemulsion system and profile its in vivo biocompatibility and efficacy against atherosclerosis in diet-induced, ApoE-/- mice fed a high-fat diet, a well-recognized murine model of experimental atherosclerosis [28].