While mutations of p63 are extremely rare in human cancers, several tumors (> 80% of primary head and neck squamous cell carcinomas [HNSCCs], squamous cell epithelial lung malignancies, and basal-like subtype of breast cancer [12–14], often display elevated levels of ΔNp63, due, in some cases, to gene amplification. The gene discussed is TP63; the disease is breast cancer.