PSIP1 and cancer: More recently, PSIP1/LEDGF has been shown to regulate homologous recombination DNA repair pathway by guiding the tethering of Retinoblastoma binding protein 8 (RBBP8; also known as CtBP-Interacting Protein) to specific areas of chromatin (H3K36me3) in a DNA damage-dependent manner, providing a mechanism for its ability to protect cancer cells from DNA damage [35].